Dallas, Texas - The American Heart Association and Lawrence Livermore National Laboratory (LLNL) have formed a strategic business relationship to overcome the burden of drug discovery, cost and access.
Announced at the American Heart Association’s Scientific Sessions by its CEO, Nancy Brown, the two organizations will leverage the world’s most powerful super computers to accelerate drug discovery. LLNL scientists and engineers in collaboration with AHA-funded scientists will create a simulated environment that rapidly and precisely predicts how drugs bind to their target proteins and will test these predictions in experimental systems to generate a robust drug pipeline of new and targeted therapies.
This collaboration is part of the Association’s newly formed Center for Accelerated Drug Discovery, reinforcing the AHA’s commitment to improve people’s health by accelerating the pace at which drug-protein interactions are identified and documented before actual clinical trials begin.
It takes an average of 10 years for a new medicine to be commercialized in the marketplace and an average cost of $2.6 billion.¹ As the population continues to age, the need for medications to treat chronic conditions, like heart disease, Alzheimer’s disease and diabetes, will continue to increase, challenging the current system to remove barriers to affordable health care and preventive medicine.
LLNL has applied its expertise in computational chemistry to model biological molecules since the early 1990s and has developed and applied laboratory-based methods to study the effects of drug effectiveness and side effects in humans and animals since the 1960s. More recently, LLNL has used computational biology to predict human outcomes for drug safety and efficacy.
In this new partnership, the American Heart Association, the world’s leading voluntary organization dedicated to building healthier lives, free of cardiovascular diseases and stroke, and LLNL aim to develop a unique combination of computational and experimental tools that will allow the biomedical community to validate targeted drug hypotheses that have higher probabilities of success and reduces time to market by potentially 50 percent.
To achieve this goal, the Association and LLNL will collaboratively develop and validate new high-performance computing (HPC) tools to quantitatively predict binding as a quantitative guide to on- and off-target molecular interactions.
“Some form of cardiovascular disease affects more than one in every three adult Americans,” said Nancy Brown, CEO American Heart Association. “As part of the American Heart Association’s Center for Accelerated Drug Discovery, we are committed to take the guess work out of drug effectiveness by collaborating with Lawrence Livermore National Laboratory to help patients alleviate not only heart disease, but also suffering for all people managing other chronic conditions.”
“The computing infrastructure at LLNL will enable machine learning and ultimately get safe drugs to the marketplace quicker,” said Felice Lightstone, LLNL’s principal investigator on the project. “By bringing world class, leading edge engineering and high impact biological fields together, we can develop a comprehensive reference atlas of cell-protein targets to accelerate and hone drug discovery.”
The research and development work under the Cooperative Research and Development Agreement (CRADA) intends to integrate machine learning (ML) approaches to the discovery pipeline to address a critical gap in the ability to predict drug safety and efficacy.
Heart disease is the number 1 killer worldwide. Stroke ranks second globally and is a leading cause of severe disability. An estimated 17.7 million people die from cardiovascular disease annually, representing 31% of all global deaths and of these deaths, an estimated 7.4 million were due to coronary heart disease and 6.7 million were due to stroke. The American Heart Association is working toward improving the cardiovascular health of all Americans by 20 percent, and reducing deaths from cardiovascular diseases and stroke by 20 percent, all by the year 2020. Precision medicine could ultimately reduce the overall cost to the system by developing targeted and affordable medicines for patients.
¹Biopharmaceutical Research & Development -- PhRMA